Alexandria the Farthest (Khujand, Tajikstan)
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Alexandria Eschate (Greek Ἀλεξάνδρεια Ἐσχάτη, Latin: Alexandria Ultima, English meaning "Alexandria the Farthest") or Alexandria Eskhata was founded by Alexander III of Macedon (commonly referred to as Alexander the Great) in August 329 BCE[1] as his most northerly base in Central Asia.

The city was also located around 400 km (249 mi) west of the Tarim Basin, today's region of Xinjiang in China, where the Yuezhi, an Indo-European people were established. There are indications that Greek expeditions were led as far as Kashgar in Xinjiang. According to the Greek historian Strabo, the Greeks "extended their empire even as far as the Seres and the Phryni" (Strabo XI.II.I), possibly leading to the first known contacts between China and the West around 200 BCE.

The descendants of the Greeks in Ferghana may be the Dayuan (lit. "Great Ionians") identified in the Chinese historical record of the Han Dynasty, starting with the embassies of Zhang Qian around 130 BCE. If so, they were the actors of the first major interaction between an urbanized Indo-European culture and the Chinese civilization, which led to the opening up the Silk Road from the 1st century BCE. (cont...)